On formulary as per: Royal College of Emergency Medicine and National Poisons Information Service Guideline on Antidote Availability for Emergency Departments (January 2017) One dose (2 vials) in the Pharmacy Emergency Drug Cupboard fridge for ED use within antidote guidelines It is not suitable for use in over-anticoagulation caused by rivaroxaban, apixaban or edoxaban. Restricted - Prescribing on the recommendation of a consultant Haematologist only, for rapid reversal of dabigatran in life-threatening or uncontrolled bleeding or for emergency surgery/urgent procedures. NICE TA 697 Andexanet alfa for reversing anticoagulation from apixaban or rivaroxaban HERTFORDSHIRE MEDICINES MANAGEMENT COMMITTEE (HMMC): NICE TECNOLOGY APPRAISALS - RECOMMENDED ANDEXANET ALFA FOR REVERSING ANTICOAGULATION FROM APIXABAN OR RIVAROXABAN - NICE TA697, MAY 2021 Not to be used until guidelines updated and approved. Trust Anticoagulant Pathway to be updated for use - currently being reviewed by Haematology. Note: Andexanet alfa is recommended only in research for reversing anticoagulation from apixaban or rivaroxaban in adults with life-threatening or uncontrolled bleeding in the skull (intracranial haemorrhage ICH), in the form of an ongoing randomised trial mandated by the regulator.Ĭommissioned by CCG (see decision) via Blueteq

The company provides andexanet alfa according to the commercial arrangement. The bleed is in the gastrointestinal tract, and

Andexanet cost